The Human Proteome Organization Proteomics Standards Initiative (HUPO-PSI) is a global collaborative effort aimed at creating and maintaining community-driven standards, data formats, and controlled vocabularies for proteomics and mass spectrometry-based research. Through its working groups and annual workshops, HUPO-PSI encourages collaboration and ensures thorough public review of proposals before their adoption as standards. By advocating for open data sharing, the initiative accelerates advancements in proteomics and related scientific fields.