COMBINE is a network formed by the communities developing standards and formats to share computational models. Working together, it is expected that the federated projects will develop a set of interoperable standards covering all the aspects of computational modeling. Building on the experience of mature projects, which already have stable specifications, software support, user-base and community governance, COMBINE helps foster or support fledging efforts aimed at filling gaps or new needs.

The standard description formats would ultimately cover the various types of models used in biology, the different views of a model and the different steps of the modeling and simulation activity. This matrix is currently sparse, but new projects are launched on a regular basis. See the our page on standards for a list of existing efforts.


The various COMBINE activities are organized by a variety of individuals acknowledged on the relevant pages. The global COMBINE effort is led by the COMBINE Coordination Board with the current members of this board listed below and can be contacted at: combine-coord @ googlegroups.com. The process by which members are appointed to this board is described here.

Gary Bader BioPAX Delegate

Gary D. Bader (Ph.D. Biochemistry) works on biological network analysis and pathway information resources as an Associate Professor at The Donnelly Centre at the University of Toronto. He has been involved in leading development of protein interaction and pathway databases and standards, including the BioPAX biological pathways exchange language.

Michael Hucka SBML Delegate

Michael Hucka (Ph.D. in Computer Science and Engineering), staff scientist at Caltech. He has chaired the SBML effort by community consensus since 2003. Today he works on all aspects of SBML and is involved with BioModels.net activities.

Chris Myers SBOL Delegate

Chris Myers (Ph.D. in Electrical Engineering) is a Professor of Electrical and Computer Engineering at the University of Utah. He conducts research in design automation for asynchronous electronic circuits, analog/mixed-signal circuits, and genetic circuits for which he was named an IEEE Fellow in 2013. He has been working in the fields of systems and synthetic biology for more than 10 years which led to the development of the iBioSim software and the textbook Engineering Genetic Circuits. During this time, he has been heavily involved in standards, previously serving as an SBML editor and currently as a member of the SBOL advisory board.

David Nickerson CellML Delegate

David Nickerson (PhD in Bioengineering) is a senior research fellow at the Auckland Bioengineering Institute at the University of Auckland, New Zealand. He leads the Auckland Renal Physiome project as well as being involved in many computational modelling projects spanning the cellular, tissue, and whole organ spatial scales. David is involved in the development and application of the CellML and SED-ML standards and related software tools. He is also involved in the Physiome Model Repository.

Falk Schreiber SBGN Delegate

Falk Schreiber (Ph.D in Computer Science) is a Professor in the Faculty of Information Technology at Monash University (Melbourne). His interests include computational systems biology, modeling of metabolic systems, analysis and visualization of biological networks, and visual analytics in the life sciences. His group is developing various software tools including Vanted and SBGN-ED, as well as databases including MetaCrop. He is also involved in the development of SBGN.

Dagmar Waltemath SED-ML Delegate

Dagmar Waltemath (Ph.D. in Computer Science) leads the junior research group SEMS at the University of Rostock. She also coordinates the data and model management activities of the German Network for Bioinformatics Infrastructure. Dagmar's research interest is in strategies for the management, provenance and integration of model-related data in systems biology and medicine. Her group focuses on developing methods to reproducibly simulate computational biology models including storing, annotating, searching and retrieving models and model-related data. Dagmar Waltemath has been actively involved in the development of SED-ML and SBML. She furthermore contributes to the development and tool support for the COMBINE Archive format.

Padraig Gleeson NeuroML Delegate

Padraig Gleeson (Ph.D. in Computational Neuroscience) is a Principal Research Associate at University College London. His work involves the development of the infrastructure to facilitate generation, analysis and sharing of biophysically detailed neuronal models. He is a member of the NeuroML Editorial Board, and has been an active technical contributor to the standard for many years. He is also the main developer of the application neuroConstruct and is project manager of the Open Source Brain Initiative.

Martin Golebiewski Martin Golebiewski (Biochemist) works at the Heidelberg Institute for Theoretical Studies (HITS), a private non-profit institute in Heidelberg (Germany). His main interests are data management and integration for systems biology. He chairs the 'data processing and integration' working group of the ISO technical committee for biotechnology (ISO/TC 276) and coordinates the NormSys project that builds a bridge between community standards and standardization bodies. Moreover, he is involved in the reaction kinetics database SABIO-RK , in the Virtual Liver Network and in the Infrastructure for Systems Biology Europe (ISBE).
Nicolas Le Novère Nicolas Le Novère (Ph.D. in Molecular Pharmacology). Leads a research group at the Babraham Institute. His interests include signal transduction and computational modeling of biological processes. His group maintains BioModels Database and SBO and http://identifiers.org. He is also involved in the development of SBML and SBGN.